In the pinkZdrowy styl życia, odchudzanie, leczenie i sposoby na długowieczność: Semaglutyd, tirzepatyd, retatrutydPorównanie siły działania Semaglu …Dodaj odpowiedź

Dodaj odpowiedź: Porównanie siły działania Semaglutide (Ozempic, Wegovy), Tirzepatide (Mounjaro) i Retatrutide

<blockquote><div class="quotetitle">Cytat z <a class="profile-link highlight-admin" href="#">V</a> data 26 kwietnia, 2026, 9:23 am</div>Podobieństwo do receptora (siła wiązania) gdzie mniej = lepiej/mocniej
Porównanie potencjału receptora GLP-1 
<div class="bbTable">
<table>
<tbody>
<tr>
<td>Lek</td>
<td>GLP-1 Ki (nM)</td>
<td>Siła względna</td>
</tr>
<tr>
<td>Sema</td>
<td>0,38</td>
<td>~1x (pasuje do naturalnego GLP-1)</td>
</tr>
<tr>
<td>Survodite</td>
<td>1.0</td>
<td>~2,5x słabszy niż naturalny</td>
</tr>
<tr>
<td>Tirz</td>
<td>4.23</td>
<td>~12x słabszy niż naturalny</td>
</tr>
<tr>
<td>Reta</td>
<td>7.2</td>
<td>~20x słabszy niż naturalny</td>
</tr>
<tr>
<td>Maz</td>
<td>28,6</td>
<td>~80x-100x Słabszy niż naturalny</td>
</tr>
</tbody>
</table>
</div>
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alt="" />Porównanie siły wiązania dla GIP
Bliźnięta o wartościach KI dla GIP:
<blockquote class="bbCodeBlock bbCodeBlock--expandable bbCodeBlock--quote js-expandWatch" data-attributes="" data-quote="" data-source="">
<div class="bbCodeBlock-content">
<div class="bbCodeBlock-expandContent js-expandContent ">Tirzepatid GIP (0,135): Jest około 3-4 razy silniejszy niż naturalny GIP. Retatrutide GIP (0,057): Osiąga poziom 8-9 razy silniejszy .</div>
</div>
</blockquote>
Ograniczenia Ki (powinowactwa wiązania) w porównaniu z wynikami w świecie rzeczywistym Dlaczego „słaba” wartość na papierze może nadal oznaczać „silny” lek w organizmie. 
<div class="bbTable">
<table>
<tbody>
<tr>
<td>Metryczny</td>
<td>Co mierzy Ki</td>
<td>Ograniczenie (dlaczego „kłamie”)</td>
<td>Zastosowanie w świecie rzeczywistym</td>
</tr>
<tr>
<td>Wiązanie kontra działanie</td>
<td>Powinowactwo: Stopień „lepkości” leku względem receptora.</td>
<td>Skuteczność (EC50): Ki nie mierzy siły, z jaką lek „przełącza przełącznik” po przyłączeniu.</td>
<td>Mazdutide może mieć „luźny” chwyt (28,6), ale nadal może być bardzo skutecznym „płetwcem przełączającym”.</td>
</tr>
<tr>
<td>Objętość dawki</td>
<td>Surowe wiązanie: siła wiązania cząsteczek 1 do 1.</td>
<td>Stężenie: Możesz pokonać „słabe” wiązanie, po prostu stosując znacznie wyższą dawkę.</td>
<td>Ponieważ Maz jest „słaby” w stosunku do GLP-1, można dawkować od 9 mg do 16 mg , zalewając receptory, aby wymusić aktywację.</td>
</tr>
<tr>
<td>Sufit efektu ubocznego</td>
<td>Siła działania: Dawka leku potrzebna do jego zadziałania.</td>
<td>Tolerancja: Wysokie powinowactwo (jak Sema) często osiąga „sufit nudności” zanim inne receptory mogą zostać zaangażowane.</td>
<td>Słabe powinowactwo Maz do GLP-1 jest cechą konstrukcyjną leku ; pozwala on uniknąć skrajnych nudności, dzięki czemu można stosować dawki glukagonu spalające tłuszcz.</td>
</tr>
<tr>
<td>Jakość sygnalizacji</td>
<td>Zajętość: Czy odbiornik jest „zajęty”?</td>
<td>Sygnalizacja stronnicza: Ki nie pokazuje, która ścieżka komórkowa jest aktywowana (np. utrata wagi czy nudności).</td>
<td>Nowoczesne peptydy są zaprojektowane tak, aby wywoływać korzyści metaboliczne, jednocześnie ignorując ścieżki, które powodują dyskomfort.</td>
</tr>
<tr>
<td>Synergia</td>
<td>Izolacja: Wartości mierzone są dla każdego receptora osobno.</td>
<td>Efekt otoczenia: Receptory (GIP, GLP-1, GCGR) komunikują się ze sobą i wzajemnie wzmacniają.</td>
<td>Ośmiokrotna siła GIP białka Reta sprawia, że jego „słaby” sygnał GLP-1 (7,2) jest znacznie skuteczniejszy, niż gdyby był stosowany osobno.</td>
</tr>
</tbody>
</table>
</div>
&nbsp;
<blockquote class="bbCodeBlock bbCodeBlock--expandable bbCodeBlock--quote js-expandWatch" data-attributes="" data-quote="" data-source="">
<div class="bbCodeBlock-content">
<div class="bbCodeBlock-expandContent js-expandContent ">Podsumowanie: Patrzenie tylko na wartości Ki jest jak patrzenie na rozmiar przewodu paliwowego samochodu bez sprawdzania rozmiaru silnika ani ilości paliwa w zbiorniku. Mazdutide działa, ponieważ wykorzystuje objętość (wysoka dawka) i dźwignię (glukagon), aby pokonać to, co wygląda na „słabe” wiązanie w arkuszu kalkulacyjnym.</div>
</div>
</blockquote>
&nbsp;</blockquote>

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